Layered double hydroxide-based nanomaterials for biomedical applications

T Hu, Z Gu, GR Williams, M Strimaite, J Zha… - Chemical Society …, 2022 - pubs.rsc.org
Against the backdrop of increased public health awareness, inorganic nanomaterials have
been widely explored as promising nanoagents for various kinds of biomedical applications …

Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Manipulating intratumoral fenton chemistry for enhanced chemodynamic and chemodynamic‐synergized multimodal therapy

Y Zhou, S Fan, L Feng, X Huang, X Chen - Advanced Materials, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral
Fenton reaction for generating highly toxic hydroxyl free radicals (• OH) to achieve selective …

Nanocatalytic theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient cancer therapy

LH Fu, Y Wan, C Qi, J He, C Li, C Yang, H Xu… - Advanced …, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) is an emerging therapy method that kills cancer cells by
converting intracellular hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (• OH) …

Ablation of gap junction protein improves the efficiency of nanozyme‐mediated catalytic/starvation/mild‐temperature photothermal therapy

Y Li, Y Zhang, Y Dong, OU Akakuru, X Yao… - Advanced …, 2023 - Wiley Online Library
Reactive oxygen species (ROS)‐mediated tumor catalytic therapy is typically hindered by
gap junction proteins that form cell‐to‐cell channels to remove cytotoxic ROS, thereby …

Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Recent advances in nanomaterial‐based nanoplatforms for chemodynamic cancer therapy

SL Li, P Jiang, FL Jiang, Y Liu - Advanced Functional Materials, 2021 - Wiley Online Library
Triggered by the endogenous chemical energy in the tumor microenvironment (TME),
chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic …

Strategies for enhancing cancer chemodynamic therapy performance

D Jana, Y Zhao - Exploration, 2022 - Wiley Online Library
Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen
species‐based cancer treatment modalities. CDT utilizes endogenous H2O2 in tumor …

[HTML][HTML] A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Z Li, H Cai, Z Li, L Ren, X Ma, H Zhu, Q Gong… - Bioactive materials, 2023 - Elsevier
To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody
in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction of …

[HTML][HTML] Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2, 3-dioxygenase-blockade tumor immunotherapy

L Dai, M Yao, Z Fu, X Li, X Zheng, S Meng… - Nature …, 2022 - nature.com
Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …