Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …

Prostate cancer (PC) is the most commonly diagnosed neoplasm and the third most
common cause of cancer-related death amongst men in the Western world. PC is a clinically …

Increased androgen receptor (AR) activity drives therapeutic resistance in advanced
prostate cancer. The most common resistance mechanism is amplification of this locus …

HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR)
activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in …

Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common
mechanism of adaptive resistance to targeted therapy in cancer. An archetypal example is …

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of
multiple genes including MYC, and supraphysiological androgen is effective in some …

Cancer is characterized by hypomethylation-associated silencing of large chromatin
domains, whose contribution to tumorigenesis is uncertain. Through high-resolution genome …

Abstract Analysis of DNA methylation is a valuable tool to understand disease progression
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …

Prostate cancer is the most common cancer in men and the second leading cause of cancer
deaths in men in France. Apart from the genetic alterations in prostate cancer, epigenetics …