IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …

Background Chronic periodontitis (CP), defines as destruction of the supporting tissues of
the teeth and resorption of the alveolar bone. It is widespread in human populations and …

Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …

Although evidence suggests that T cells are critical for immunity to malaria, reliable T cell
correlates of exposure to and protection from malaria among children living in endemic …

Host responses to infection with the malaria parasite Plasmodium falciparum vary among
individuals for reasons that are poorly understood. Here we reveal metabolic perturbations …

Abstract RTS, S/AS01E, the first approved malaria vaccine, demonstrated moderate efficacy
during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) …

Background The increased levels of blood cytokines is the main immunopathological
process that were attributed to severe clinical outcomes in cases of influenza A, influenza B …

Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has important roles
in the periodontal diseases. The IL10-1082,-819, and-592 polymorphisms in the promoter …

Human genetic background strongly influences susceptibility to malaria infection and
progression to severe disease and death. Classical genetic studies identified …

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining
clinical management and providing a framework for understanding pathogenesis. Severe …