The neurovascular unit in glaucomatous neurodegeneration
LK Wareham, DJ Calkins - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Glaucoma is a neurodegenerative disease of the visual system and leading cause of
blindness worldwide. The disease is associated with sensitivity to intraocular pressure (IOP) …
blindness worldwide. The disease is associated with sensitivity to intraocular pressure (IOP) …
Advances in understanding glaucoma pathogenesis: a multifaceted molecular approach for clinician scientists
Glaucoma, a leading cause of irreversible blindness worldwide, is a spectrum of
neurodegenerative diseases characterized by the gradual deterioration of retinal ganglion …
neurodegenerative diseases characterized by the gradual deterioration of retinal ganglion …
Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function
Y van der Merwe, AE Faust, ET Sakalli, CC Westrick… - Scientific reports, 2019 - nature.com
Injury to retinal ganglion cells (RGC), central nervous system neurons that relay visual
information to the brain, often leads to RGC axon degeneration and permanently lost visual …
information to the brain, often leads to RGC axon degeneration and permanently lost visual …
Enhanced glaucomatous damage accompanied by glial response in a new multifactorial mouse model
S Reinehr, RM Girbig, KK Schulte, J Theile… - Frontiers in …, 2023 - frontiersin.org
Introduction Glaucoma is a complex, multifactorial neurodegenerative disease, which can
lead to blindness if left untreated. It seems that, among others, immune processes, elevated …
lead to blindness if left untreated. It seems that, among others, immune processes, elevated …
Nitric oxide: a drug target for glaucoma revisited
G Garhöfer, L Schmetterer - Drug Discovery Today, 2019 - Elsevier
Highlights•Nitric oxide plays a major role in the regulation of intraocular pressure.•Nitic oxide
directly acts on trabecular meshwork cells thereby increasing outflow.•Novel nitric oxide …
directly acts on trabecular meshwork cells thereby increasing outflow.•Novel nitric oxide …
Dysfunctional cGMP signaling leads to age-related retinal vascular alterations and astrocyte remodeling in mice
JM Holden, S Al Hussein Al Awamlh… - International Journal of …, 2022 - mdpi.com
The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP)
pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha …
pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha …
cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma
AA Haider, TS Rex, LK Wareham - Biomolecules, 2022 - mdpi.com
Glaucoma is a progressive age-related disease of the visual system and the leading cause
of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only …
of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only …
Impairment of membrane repolarization accompanies axon transport deficits in glaucoma
RA Fischer, ML Risner, AL Roux… - Frontiers in …, 2019 - frontiersin.org
Glaucoma is a leading cause of blindness worldwide, resulting from degeneration of retinal
ganglion cells (RGCs), which form the optic nerve. In glaucoma, axon transport deficits …
ganglion cells (RGCs), which form the optic nerve. In glaucoma, axon transport deficits …
cGMP signaling: a potential therapeutic target for neurodegeneration in glaucoma?
JM Holden, LK Wareham - Neural Regeneration Research, 2023 - journals.lww.com
Neurodegeneration of the central nervous system (CNS) underscores many of humanity's
most debilitating diseases, including Alzheimer's disease, Parkinson's disease, and multiple …
most debilitating diseases, including Alzheimer's disease, Parkinson's disease, and multiple …
Pressure-dependent modulation of inward-rectifying K+ channels: implications for cation homeostasis and K+ dynamics in glaucoma
RA Fischer, AL Roux, LK Wareham… - American Journal of …, 2019 - journals.physiology.org
Glaucoma is the leading cause of blindness worldwide, resulting from degeneration of
retinal ganglion cells (RGCs), which form the optic nerve. Prior to structural degeneration …
retinal ganglion cells (RGCs), which form the optic nerve. Prior to structural degeneration …