[HTML][HTML] Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
characterized by impaired cognitive function due to progressive loss of neurons in the brain …
Ovarian ageing: the role of mitochondria in oocytes and follicles
P May-Panloup, L Boucret… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …
20% of patients consulting for infertility show signs of premature ovarian ageing. This …
Mitochondrial genetic medicine
DC Wallace - Nature genetics, 2018 - nature.com
Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their
characterization has provided a new perspective on the etiology of the common metabolic …
characterization has provided a new perspective on the etiology of the common metabolic …
Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease
Alzheimer disease (AD) and Parkinson disease (PD) are the two most common age-related
neurodegenerative diseases characterized by prominent neurodegeneration in selective …
neurodegenerative diseases characterized by prominent neurodegeneration in selective …
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
A large part of the aging phenotype, including immunosenescence, is explained by an
imbalance between inflammatory and anti-inflammatory networks, which results in the low …
imbalance between inflammatory and anti-inflammatory networks, which results in the low …
Mitochondrial DNA mutations in disease and aging
DC Wallace - Environmental and molecular mutagenesis, 2010 - Wiley Online Library
The human mitochondrial genome involves over 1,000 genes, dispersed across the
maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA …
maternally inherited mitochondrial DNA (mtDNA) and the biparentally inherited nuclear DNA …
Mitochondrial energetics and therapeutics
DC Wallace, W Fan, V Procaccio - Annual Review of Pathology …, 2010 - annualreviews.org
Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …
Energetics, epigenetics, mitochondrial genetics
DC Wallace, W Fan - Mitochondrion, 2010 - Elsevier
The epigenome has been hypothesized to provide the interface between the environment
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of …
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of …
Effects of purifying and adaptive selection on regional variation in human mtDNA
E Ruiz-Pesini, D Mishmar, M Brandon, V Procaccio… - Science, 2004 - science.org
A phylogenetic analysis of 1125 global human mitochondrial DNA (mtDNA) sequences
permitted positioning of all nucleotide substitutions according to their order of occurrence …
permitted positioning of all nucleotide substitutions according to their order of occurrence …
An enhanced MITOMAP with a global mtDNA mutational phylogeny
E Ruiz-Pesini, MT Lott, V Procaccio… - Nucleic acids …, 2007 - academic.oup.com
The MITOMAP () data system for the human mitochondrial genome has been greatly
enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) …
enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) …