Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Calcium (Ca2+) uptake into the mitochondrial matrix is critically important to cellular function.
As a regulator of matrix Ca2+ levels, this flux influences energy production and can initiate …

Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Myofascial pain syndrome is an important health problem. It affects a majority of the general
population, impairs mobility, causes pain, and reduces the overall sense of well‐being …

In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

In the current study, the three-dimensional (3D) topologies of dyadic clefts and associated
membrane organelles were mapped in mouse ventricular myocardium using electron …