The risk of hemorrhage when using coumarin anticoagulants sharply increases when the
International Normalised Ratio (INR) is≥ 6.0. We performed a prospective cohort study with …

Warfarin is employed more frequently than acenocoumarol because of its longer half-life (36
h), theoretically providing more stable anticoagulation, and avoiding factor VII fluctuations …

Variability in the control of oral anticoagulant therapy has been associated with a
heightened risk of complications. We compared control of anticoagulation between two …

To investigate whether the different pharmacokinetics of acenocoumarol (t1/2= 11 h) and
phenprocoumon (t1/2= 140 h) result in a different quality of anticoagulation, we studied …

INTRODUCTION: Vitamin K antagonists of the coumarin type are widely used oral
anticoagulants. OBJECTIVE: We developed a transition algorithm for the maintenance …

FUNDAMENTO: Os anticoagulantes orais são amplamente utilizados na cardiologia.
Contudo, uma avaliação sobre o seu uso na prática clínica ainda é necessária. OBJETIVOS …

FUNDAMENTO: Os anticoagulantes orais são amplamente utilizados na cardiologia.
Contudo, uma avaliação sobre o seu uso na prática clínica ainda é necessária. OBJETIVOS …

Background The quality of oral anticoagulant therapy may be related to which type of
coumarin is used. The aim was to investigate whether phenprocoumon or warfarin provide …

Background Treatment with vitamin K antagonists (VKA) requires a high proportion of time in
the therapeutic range (TTR) and a low international normalised ratio (INR) variability to be …

A controlled clinical trial was performed in more than 250 patients with myocardial infarction
or angina pectoris to determine whether any difference in clinical effect could be observed …