Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …

Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …

Abstract Background Histone deacetylases (HDACs) are one of the essential epigenetic
targets in cancer treatment. These enzymes play key roles in post-translation modification …

Cancer, characterized by a deregulation of the cell cycle which mainly results in a
progressive loss of cellular differentiation and uncontrolled cellular growth, remains a …

Uncontrolled inflammation predisposes to pleiotropic effects leading to cancer development
thanks to promoting all stages of tumorigenesis. Therefore, cancer-associated inflammation …

Abstract A series of novel 1, 2, 3-triazole-linked ciprofloxacin-chalcones 4a-j were
synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable anti …

The dynamic equilibrium of tubulin-microtubule is an essential aspect of cell survivality.
Modulation of this dynamics has become an important target for the cancer drug …

The occurrence of cancer is closely related to metabolism and epigenetics. Histone
deacetylases (HDACs) play a crucial role in the regulation of gene expression as epigenetic …