Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and
fatalities each year. The origin of TTX is unknown, but in the pufferfish, it seems to be …

This review provides a comprehensive coverage of the history, biology and chemistry of
tetrodotoxin (TTX). It traces the origin of this remarkable molecule all the way back to the …

Increasing atmospheric CO2 levels are largely absorbed by the ocean, decreasing surface
water pH. In combination with increasing ocean temperatures, these changes have been …

Brugada syndrome (BrS) is a hereditary disorder, characterized by a specific
electrocardiogram pattern and highly related to an increased risk of sudden cardiac death …

Although late sodium current (I Na-late) has long been known to contribute to plateau
formation of mammalian cardiac action potentials, lately it was considered as possible target …

Toads of the genus Atelopus are chemically defended by a unique combination of
endogenously synthesized cardiotoxins (bufadienolides) and neurotoxins which may be …

В учебном пособии на основе анализа мировой научной литературы приведены
современные данные о важнейших ядовитых представителях фауны Земли, а также …

天然产物无论是过去还是现在都为人类的健康起着非常重要的作用. 河豚毒素(tetrodotoxin,
TTX) 是具有非常复杂且奇特结构以及特殊生物活性的著名小分子天然产物, 其结构确定 …

This chapter revises current knowledge on marine biotoxins that are known nowadays,
considering all the distinct groups based on chemical structure and lipophilic or hydrophilic …

Tetrodotoxin (TTX) has been believed for a long time to be a selective inhibitor of voltage-
gated fast Na+ channels in excitable tissues, including mammalian myocardium. Recently …