La was first identified as a polypeptide component of ribonucleic protein complexes targeted
by antibodies in autoimmune patients and is now known to be a eukaryote cell‐ubiquitous …

Most severe forms of intellectual disability (ID) have specific genetic causes. Numerous X
chromosome gene defects and disease-causing copy-number variants have been linked to …

Discovery of most autosomal recessive disease-associated genes has involved analysis of
large, often consanguineous multiplex families or small cohorts of unrelated individuals with …

RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene
regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often …

Primordial dwarfism (PD) is a disease in which severely impaired fetal growth persists
throughout postnatal development and results in stunted adult size. The condition is highly …

Cellular senescence is associated with pleiotropic physiopathological processes, including
aging and age-related diseases. The persistent DNA damage is a major stress leading to …

Background: Heart failure (HF) is among the leading causes of morbidity and mortality, and
its prevalence continues to rise. LARP7 (La ribonucleoprotein domain family member 7) is a …

Regulation of gene expression is critical in determining cell identity, development, and
responses to the cellular environment. DNA is the inherited source of genetic information …

Objective—Macrophage foam cell formation is a key feature of atherosclerosis. Recent
studies have shown that specific microRNAs (miRs) are regulated in modified low-density …

The La-related protein 7 (LARP7) forms a complex with the nuclear 7SK RNA to regulate
RNA polymerase II transcription. It has been implicated in cancer and the Alazami …