Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to
contribute to age-related diseases. Although aging-associated immune dysfunction, or …

High‐dimensional immunoprofiling is essential for studying host response to
immunotherapy, infection, and disease in murine model systems. However, the difficulty of …

As researchers uncover new roles for the microbiome in health and disease, recent studies
have emerged linking the microbiome to aspects of aging. Mossad and colleagues …

Abstract Background Although Korean Red Ginseng (KRG) is safe, this finding was only
evaluated in 3-mo-long studies. Its safety was verified through a 6-mo KRG administration …

We report an in situ vaccination, adaptable to nearly any type of cancer, that combines
radiotherapy targeting one tumor and intratumoral injection of this site with tumor-specific …

Aging is characterized by gradual immune dysfunction and increased disease risk. Genomic
instability is considered central to the aging process, but the underlying mechanisms of DNA …