DUSP1 promotes microglial polarization toward M2 phenotype in the medial prefrontal cortex of neuropathic pain rats via inhibition of MAPK pathway

X Wang, Y Jiang, J Li, Y Wang, Y Tian… - ACS chemical …, 2021 - ACS Publications
Shifting microglial polarization from M1 toward M2 phenotype represents a promising
therapeutic strategy for neuropathic pain (NP). Dual-specificity phosphatase-1 (DUSP1) is a …

Sucrose intake and preference by Wistar Han rats are not influenced by sex or food/water deprivation

D Fonseca-Rodrigues, J Goncalves, I Laranjeira… - Pharmacology …, 2022 - Elsevier
Anhedonia is the decreased ability to experience pleasure from rewarding or enjoyable
activities, a core symptom of depression. The sucrose preference test (SPT), based on a two …

Microglia senescence is related to neuropathic pain–associated comorbidities in the spared nerve injury model

V Borgonetti, N Galeotti - Pain, 2023 - journals.lww.com
The increased presence of senescent cells in different neurological diseases suggests the
contribution of senescence in the pathophysiology of neurodegenerative disorders …

Gallic acid attenuates the Chronic construction injury of sciatic nerve induced neuropathic pain in mice

S Kaur, A Muthuraman - Research Journal of Pharmacy and …, 2023 - indianjournals.com
Gallic acid (GA) is one of the natural flavonoids and it is known to protect the neuronal
system from various endogenous neurodegenerative processes. The present study is …

Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier

Y Wang, C Wang, X Yang, K Ni, L Jiang… - Anesthesia & …, 2022 - journals.lww.com
BACKGROUND: Dysfunction of the blood-spinal cord barrier (BSCB) contributes to the
occurrence and development of neuropathic pain (NP). Previous studies revealed that the …

Role of neuroinflammation in the symptoms associated to neuropathic pain: targeting microglia with innovative treatments

V Borgonetti - 2022 - flore.unifi.it
The immune system in mammals contains a wide array of cells which serves to maintain
normal physiologic conditions and promote the repairing processes of damaged tissues …

Immune contributions of the meninges and choroid plexus in animal models of central and peripheral nervous system neuropathy

B Keating - 2021 - unsworks.unsw.edu.au
dc. description. abstract The meninges have long been accepted as purely structural,
protecting the central nervous system (CNS). Similarly, the choroid plexus (CP) was thought …