Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

NS Yarla, A Bishayee, G Sethi, P Reddanna… - Seminars in cancer …, 2016 - Elsevier
Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …

Systemic effects reflected in specific biomarker patterns are instrumental for the paradigm change in prostate cancer management: a strategic paper

O Golubnitschaja, P Kubatka, A Mazurakova, M Samec… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer (PCa) incidence is increasing globally. The costs of
treating PCa are currently increasing more rapidly than those of any other cancer, due to an …

Synthesis of new secretory phospholipase A2-inhibitory indole containing isoxazole derivatives as anti-inflammatory and anticancer agents

SR Pedada, NS Yarla, PJ Tambade… - European journal of …, 2016 - Elsevier
Abstract Secretory phospholipase A 2 (sPLA 2) is an important enzyme that plays a key role
in various inflammatory diseases including cancer and its inhibitors have been developed …

Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation

D Malayil, NC House, D Puthenparambil… - Drug and Chemical …, 2022 - Taylor & Francis
Borassus flabellifer L., belonging to the Arecaceae family, is less explored for its nutritional
and biological properties. The plant parts such as the tender kernel, tender water, Borassus …

Borassus flabellifer Linn haustorium methanol extract mitigates fluoride-induced apoptosis by enhancing Nrf2/Haeme oxygenase 1 –dependent glutathione …

JT Job, R Rajagopal, A Alfarhan… - Drug and Chemical …, 2022 - Taylor & Francis
Fluoride is the most common cause of drinking water-associated toxicity and is known to
induce various metabolic imbalances and dental/skeletal fluorosis. The present study …

Appraisals of Bangladeshi medicinal plants used by folk medicine practitioners in the prevention and management of malignant neoplastic diseases

MN Kabidul Azam, MM Rahman… - International …, 2016 - Wiley Online Library
Cancer is a group of diseases which is categorized to differentiate into diverse cell types and
move around in the body to sites of organogenesis that is key to the process of tumor …

Discovery and development of a novel mPGES-1/5-LOX dual inhibitor LFA-9 for prevention and treatment of chronic inflammatory diseases

NS Yarla, G Pathuri, H Gali, S Terzyan… - Journal of …, 2020 - Taylor & Francis
Background Non-steroidal anti-inflammatory drugs, cyclooxygenase (COX)-2 selective
inhibitors, have been explored for prevention and treatment of several inflammatory chronic …

Protective Effect of Borassus flabellifer Haustorium Extract against Alkoxyl Radical-Induced Cytotoxicity by Improving Glutathione Metabolism by Modulating Nrf2 …

JT Job, R Rajagopal, A Alfarhan, YO Kim… - Journal of the …, 2022 - Taylor & Francis
Aim The study was aimed to assess the ability of Borassus flabellifer haustorium methanolic
extract (BHE) on de novo glutathione biosynthesis in normal and pro-oxidant exposed cells …

Short linear motifs characterizing snake venom and mammalian phospholipases A2

C Peggion, F Tonello - Toxins, 2021 - mdpi.com
Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to
those of mammalian group I and II secretory PLA2s, but they possess many toxic properties …

Anti-oxidant, anti-inflammatory and antiacetylcholinesterase activity of betulinic acid and 3β-acetoxybetulinic acid from Melaleuca bracteata 'Revolution Gold'

FO Osunsanmi, GE Zharare, RA Mosa, MI Ikhile… - Tropical Journal of …, 2019 - ajol.info
Purpose: To evaluate the anti-oxidant, anti-inflammatory and anti-acetylcholine esterase
activities of betulinic acid (BA) and 3β-acetoxybetulinic acid (BAA) from Melaleuca …