Molecular and cellular mechanisms linking air pollution and bone damage

D Prada, G López, H Solleiro-Villavicencio… - Environmental …, 2020 - Elsevier
Air pollution is the second most important risk factor associated with noncommunicable
diseases after smoking. The effects of pollution on health are commonly attributable to …

The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations

KP Singh, FL Casado, LA Opanashuk… - Biochemical …, 2009 - Elsevier
The aryl hydrocarbon receptor (AhR) is known mainly as the mediator for the toxicity of
certain xenobiotics. However, there is also much information to indicate that this transcription …

The highly potent AhR agonist picoberin modulates Hh-dependent osteoblast differentiation

J Flegel, S Shaaban, ZJ Jia, B Schulte… - Journal of Medicinal …, 2022 - ACS Publications
Identification and analysis of small molecule bioactivity in target-agnostic cellular assays
and monitoring changes in phenotype followed by identification of the biological target are a …

Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling

EE Beier, JR Maher, TJ Sheu… - Environmental …, 2013 - ehp.niehs.nih.gov
Background: Exposure to lead (Pb) from environmental and industrial sources remains an
overlooked serious public health risk. Elucidating the effect of Pb on bone cell function is …

A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic …

K Sharan, JS Mishra, G Swarnkar… - Journal of Bone and …, 2011 - academic.oup.com
We recently reported that extracts made from the stem bark of Ulmus wallichiana promoted
peak bone mass achievement in growing rats and preserved trabecular bone mass and …

Dioxins interfere with differentiation of osteoblasts and osteoclasts

M Korkalainen, E Kallio, A Olkku, K Nelo, J Ilvesaro… - Bone, 2009 - Elsevier
We have previously shown that the environmental contaminant 2, 3, 7, 8-tetrachlorodibenzo-
p-dioxin (TCDD) affects bone growth, modelling and mechanical strength in vivo. In this …

Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an …

E Piek, LS Sleumer, EP van Someren, L Heuver… - Bone, 2010 - Elsevier
Bone marrow-derived human mesenchymal stem cells (hMSCs) have the in vitro capacity to
differentiate into osteoblasts, chondrocytes or adipocytes, depending on the applied …

Surface characteristics and biocompatibility of sandblasted and acid‐etched titanium surface modified by ultraviolet irradiation: An in vitro study

S Li, J Ni, X Liu, X Zhang, S Yin, M Rong… - … Research Part B …, 2012 - Wiley Online Library
Sandblasting with large grit and acid‐etching (SLA) treatment is considered to be a reliable
modification to achieve excellent titanium surface. However, contamination of hydrocarbons …

Bone and bone marrow disruption by endocrine‐active substances

D Agas, G Lacava, MG Sabbieti - Journal of cellular physiology, 2019 - Wiley Online Library
Bone is a multifaceted dynamic tissue, involved in mobility, mineral metabolism, and
mesenchymal or stromal and hematopoietic progenitor or stem cells breading. Recently, an …

Effects of combined exposure to lead and high-fat diet on bone quality in juvenile male mice

EE Beier, JA Inzana, TJ Sheu, L Shu… - Environmental …, 2015 - ehp.niehs.nih.gov
Background Lead (Pb) exposure and obesity are co-occurring risk factors for decreased
bone mass in the young, particularly in low socioeconomic communities. Objectives The …