Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Tau proteins belong to the family of microtubule-associated proteins. They are mainly
expressed in neurons where they play an important role in the assembly of tubulin …

During the past decade enormous advances have been made in our understanding of the
basic molecular machinery that is involved in the development of neuronal polarity. Far from …

Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease,
are the results of the pathological deposition of proteins normally present throughout the …

The neuronal microtubule-associated protein tau is required for the development of cell
polarity in cultured neurons. Using PC12 cells that stably express tau and tau amino …

The polarity of neurons, which is integral to their function, is a result of the segregated
distribution of molecules and organelles. The polarized distribution of cytoskeletal proteins …

Tau protein plays a role in the extension and maintenance of neuronal processes through a
direct association with microtubules. To characterize the nature of this association, we have …

NEURONS in culture can have fundamentally distinct morphologies which permit their
cytological identification and the recognition of their neurites as axons or dendrites …

Neurons, the basic information processing units of the nervous system, are characterized by
a complex polar morphology which is essential for their function. To attain their precise …

Abstract Microtubule associated protein 2 (MAP‐2) historically has been perceived primarily
as a static, structural protein, necessary along with other cytoskeletal proteins to maintain …