Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …

Single-molecule FRET (smFRET) has become a mainstream technique for studying
biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by …

Probing non-equilibrium dynamics with single-molecule spectroscopy is important for
dissecting biomolecular mechanisms. However, existing microfluidic rapid-mixing systems …

Interactions between biomolecules control the processes of life in health and their
malfunction in disease, making their characterization and quantification essential …

Single-molecule spectroscopy is a powerful method for studying the physics of molecular
systems, particularly biomolecules, such as proteins and nucleic acids. By avoiding …

The interactions of intrinsically disordered proteins (IDPs) with their molecular targets are
essential for the regulation of many cellular processes. IDPs can perform their functions …

Integral membrane proteins (IMPs) are biologically highly significant but challenging to study
because they require maintaining a cellular lipid-like environment. Here, we explore the …

Exploration and characterisation of the human proteome is a key objective enabling a
heightened understanding of biological function, malfunction and pharmaceutical design …

Mass photometry (MP) is a rapidly growing optical technique for label-free mass
measurement of single biomolecules in solution. The underlying measurement principle …

We introduce a new concept for centrifugal microfluidics that enables fully automated serial
dilution generation without any additional means besides temperature control. The key …