Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Ribosome-associated quality-control (RQC) surveys incomplete nascent polypeptides
produced by interrupted translation. Central players in RQC are the human ribosome-and …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …

The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …

The majority of protein molecules must fold into defined three-dimensional structures to
acquire functional activity. However, protein chains can adopt a multitude of conformational …

The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product
is degraded by the ribosome-mediated quality control (RQC) system. Here we report that …

The heat shock response (HSR) was originally discovered as a transcriptional response to
elevated temperature shock and led to the identification of heat shock proteins and heat …