Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Long-term potentiation (LTP) of synaptic strength occurs during learning and can last for
long periods, making it a probable mechanism for memory storage. LTP induction results in …

Although the biological bases of forgetting remain obscure, the consensus among cognitive
psychologists emphasizes interference processes, rejecting decay in accounting for memory …

In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

Neuronal activity induces intracellular Ca2+ increase, which triggers activation of a series of
Ca2+‐dependent signaling cascades. Among these, the multifunctional Ca2+/calmodulin …

CaMKII is a remarkably complex protein kinase, known to have a fundamental role in
synaptic plasticity and memory formation. Further, CaMKII has also been suggested to be a …

Numerous studies have supported the idea that de novo protein synthesis is critical for
synaptic plasticity and normal long-term memory formation. This requirement for protein …

The structural plasticity of dendritic spines is considered to be an important basis of synaptic
plasticity, learning, and memory. Here, we induced input-specific structural LTP (sLTP) in …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by senile plaques, neurofibrillary tangles, synaptic disruption and neuronal loss. Several …