Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications
J Wess - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
Muscarinic acetylcholine receptors (mAChRs; M1–M5) play key roles in regulating the
activity of many important functions of the central and peripheral nervous system. Because of …
activity of many important functions of the central and peripheral nervous system. Because of …
Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease
AI Levey - Proceedings of the National Academy of …, 1996 - National Acad Sciences
Cholinergic transmission at muscarinic acetylcholine receptors (mAChR) has been
implicated in higher brain functions such as learning and memory, and loss of synapses may …
implicated in higher brain functions such as learning and memory, and loss of synapses may …
Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor
T Miyakawa, M Yamada, A Duttaroy… - Journal of …, 2001 - Soc Neuroscience
Members of the muscarinic acetylcholine receptor family are thought to play key roles in the
regulation of a large number of important functions of the CNS. However, the precise roles of …
regulation of a large number of important functions of the CNS. However, the precise roles of …
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice
J Gomeza, H Shannon, E Kostenis… - Proceedings of the …, 1999 - National Acad Sciences
Members of the muscarinic acetylcholine receptor family (M1–M5) are known to be involved
in a great number of important central and peripheral physiological and pathophysiological …
in a great number of important central and peripheral physiological and pathophysiological …
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice
W Zhang, AS Basile, J Gomeza… - Journal of …, 2002 - Soc Neuroscience
Forebrain muscarinic acetylcholine (ACh) receptors (mAChRs; M1-M5) are predicted to play
important roles in many fundamental central functions, including higher cognitive processes …
important roles in many fundamental central functions, including higher cognitive processes …
Cholinergic dilation of cerebral blood vessels is abolished in M5 muscarinic acetylcholine receptor knockout mice
M Yamada, KG Lamping, A Duttaroy… - Proceedings of the …, 2001 - National Acad Sciences
The M5 muscarinic receptor is the most recent member of the muscarinic acetylcholine
receptor family (M1-M5) to be cloned. At present, the physiological relevance of this receptor …
receptor family (M1-M5) to be cloned. At present, the physiological relevance of this receptor …
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice
J Gomeza, L Zhang, E Kostenis… - Proceedings of the …, 1999 - National Acad Sciences
Muscarinic acetylcholine receptors (M1–M5) regulate many key functions of the central and
peripheral nervous system. Primarily because of the lack of receptor subtype-selective …
peripheral nervous system. Primarily because of the lack of receptor subtype-selective …
M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity
T Seeger, I Fedorova, F Zheng, T Miyakawa… - Journal of …, 2004 - Soc Neuroscience
Muscarinic acetylcholine receptors are known to play key roles in facilitating cognitive
processes. However, the specific roles of the individual muscarinic receptor subtypes (M1 …
processes. However, the specific roles of the individual muscarinic receptor subtypes (M1 …
[HTML][HTML] Fine tuning muscarinic acetylcholine receptor signaling through allostery and bias
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors
J Jeon, D Dencker, G Wörtwein… - Journal of …, 2010 - Soc Neuroscience
Acetylcholine (ACh) regulates many key functions of the CNS by activating cell surface
receptors referred to as muscarinic ACh receptors (M1–M5 mAChRs). Like other mAChR …
receptors referred to as muscarinic ACh receptors (M1–M5 mAChRs). Like other mAChR …