Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of
extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium …

Bacterial toxins are virulence factors that manipulate host cell functions and take over the
control of vital processes of living organisms to favor microbial infection. Some toxins directly …

Mycobacterium ulcerans, the etiological agent of Buruli ulcer, causes extensive skin lesions,
which despite their severity are not accompanied by pain. It was previously thought that this …

Infection with Mycobacterium ulcerans is characterised by tissue necrosis and
immunosuppression due to mycolactone, the necessary and sufficient virulence factor for …

Background Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins.
While closely related to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability …

Mycolactone, an immunosuppressive macrolide released by the human pathogen
Mycobacterium ulcerans, was previously shown to impair Sec61-dependent protein …

Infection with Mycobacterium ulcerans results in a necrotising skin disease known as a
Buruli ulcer, the pathology of which is directly linked to the bacterial production of the toxin …

MicroRNAs (miRNA) are a class of small non-coding RNAs that constitute an essential and
evolutionarily conserved mechanism for post-transcriptional gene regulation. Multiple …

Infection of subcutaneous tissue with Mycobacterium ulcerans can lead to chronic skin
ulceration known as Buruli ulcer. The pathogenesis of this neglected tropical disease is …

Mycolactone is a diffusible lipid secreted by the human pathogen Mycobacterium ulcerans,
which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show …