Accurate assembly of multi-end RNA-seq data with Scallop2

Q Zhang, Q Shi, M Shao - Nature computational science, 2022 - nature.com
Modern RNA-sequencing (RNA-seq) protocols can produce multi-end data, where multiple
reads originating from the same transcript are attached to the same barcode. The long-range …

Safety and completeness in flow decompositions for RNA assembly

S Khan, M Kortelainen, M Cáceres, L Williams… - … on Research in …, 2022 - Springer
Flow decomposition has numerous applications, ranging from networking to bioinformatics.
Some applications require any valid decomposition that optimizes some property as number …

Safety in multi-assembly via paths appearing in all path covers of a DAG

M Cáceres, B Mumey, E Husić, R Rizzi… - IEEE/ACM …, 2021 - ieeexplore.ieee.org
A multi-assembly problem asks to reconstruct multiple genomic sequences from mixed
reads sequenced from all of them. Standard formulations of such problems model a solution …

[图书][B] Genome-scale algorithm design: bioinformatics in the era of high-throughput sequencing

V Mäkinen, D Belazzougui, F Cunial, AI Tomescu - 2023 - books.google.com
Presenting the fundamental algorithms and data structures that power bioinformatics
workflows, this book covers a range of topics from the foundations of sequence analysis …

Minimum flow decomposition in graphs with cycles using integer linear programming

FHC Dias, L Williams, B Mumey, AI Tomescu - arXiv preprint arXiv …, 2022 - arxiv.org
Minimum flow decomposition (MFD)--the problem of finding a minimum set of weighted
source-to-sink paths that perfectly decomposes a flow--is a classical problem in Computer …

A safety framework for flow decomposition problems via integer linear programming

FHC Dias, M Cáceres, L Williams, B Mumey… - …, 2023 - academic.oup.com
Motivation Many important problems in Bioinformatics (eg assembly or multiassembly) admit
multiple solutions, while the final objective is to report only one. A common approach to deal …

Flowtigs: safety in flow decompositions for assembly graphs

F Sena, E Ingervo, S Khan, A Prjibelski, S Schmidt… - iScience, 2024 - cell.com
A decomposition of a network flow is a set of weighted walks whose superposition equals
the flow. In this article, we give a simple and linear-time-verifiable complete characterization …

Improving RNA assembly via safety and completeness in flow decompositions

S Khan, M Kortelainen, M Cáceres… - Journal of …, 2022 - liebertpub.com
Decomposing a network flow into weighted paths is a problem with numerous applications,
ranging from networking, transportation planning, to bioinformatics. In some applications we …

Efficient minimum flow decomposition via integer linear programming

FHC Dias, L Williams, B Mumey… - Journal of Computational …, 2022 - liebertpub.com
Minimum flow decomposition (MFD) is an NP-hard problem asking to decompose a network
flow into a minimum set of paths (together with associated weights). Variants of it are …

Accurate Flow Decomposition via Robust Integer Linear Programming

FHC Dias, AI Tomescu - IEEE/ACM Transactions on …, 2024 - ieeexplore.ieee.org
Minimum flow decomposition (MFD) is a common problem across various fields of Computer
Science, where a flow is decomposed into a minimum set of weighted paths. However, in …