The importance of DNA repair as a resistance mechanism in gliomas, the most aggressive
form of brain tumor, is a clinically relevant topic. Recent studies show that not all cells are …

Glioma, which accounts for more than 30% of primary central nervous system tumours, is
characterised by symptoms such as headaches, epilepsy, and blurred vision. Glioblastoma …

Gene therapy represents a promising treatment alternative for patients with malignant
gliomas. Nevertheless, in the setting of these highly infiltrative tumors, transgene delivery …

Gliomas are the most common type of brain tumor that occur in adults and children.
Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in …

Treating brain tumors presents enormous challenges, and there are still poor prognoses in
both adults and children. Application of novel targets and potential drugs is hindered by the …

In addition to stem cells providing a better understanding about the biology and origins of
gliomas, new therapeutic approaches have been developed based on the use of stem cells …

Neuroblastoma, a malignancy of multipotent embryonic neural crest cells, is the most
common extracranial solid cancer in childhood and most common cancer in infancy. Cellular …

The failure of current glioma therapies is mainly due to the ability of the tumor cells to invade
extensively the surrounding healthy brain tissue, hence escaping localized treatments …

Abstract Background Mesenchymal stem cells (MSCs) have been considered to be the
attractive vehicles for delivering therapeutic agents toward various tumor diseases. This …

The prognosis of patients diagnosed with malignant gliomas including glioblastoma
multiforme (GBM) is poor and there is an urgent need to develop and translate novel …