This publication introduces a series of eight other publications describing the non-clinical
assessment and initial clinical study of a candidate modified risk tobacco product (MRTP) …

The health risks of tobacco smoking have been documented in numerous studies and
smoking rates have declined in developed countries over the last 50 years. Today, we know …

Proponents for electronic cigarettes (E-cigs) claim that they are a safe alternative to tobacco-
based cigarettes; however, little is known about the long-term effects of exposure to E-cig …

While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine,
propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in …

Tobacco smoking and hemodynamic forces are key stimuli for the development of
endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine …

Smoking cigarettes is a major risk factor in the development and progression of
cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD). Modified …

The objective of the study was to characterize the toxicity from sub-chronic inhalation of test
atmospheres from the candidate modified risk tobacco product (MRTP), Tobacco Heating …

Background High-throughput measurement technologies such as microarrays provide
complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment …

With the wealth of publications and data available, powerful and transparent computational
approaches are required to represent measured data and scientific knowledge in a …

Modified risk tobacco products (MRTP) are designed to reduce smoking-related health risks.
A murine model of chronic obstructive pulmonary disease (COPD) was applied to …