Laminins in cellular differentiation
Basement membrane laminins (LNs) have been shown to modulate cellular phenotypes and
differentiation both in vitro and during organogenesis in vivo. At least 16 laminin isoforms …
differentiation both in vitro and during organogenesis in vivo. At least 16 laminin isoforms …
Tissue-specific parameters for the design of ECM-mimetic biomaterials
The extracellular matrix (ECM) is a complex network of biomolecules that mechanically and
biochemically directs cell behavior and is crucial for maintaining tissue function and health …
biochemically directs cell behavior and is crucial for maintaining tissue function and health …
ECM-based bioactive microencapsulation significantly improves islet function and graft performance
Microencapsulation is a promising strategy to prolong the survival and function of
transplanted pancreatic islets for diabetes therapy, albeit its translation has been impeded …
transplanted pancreatic islets for diabetes therapy, albeit its translation has been impeded …
[HTML][HTML] Non-invasive marker-independent high content analysis of a microphysiological human pancreas-on-a-chip model
The increasing prevalence of diabetes, its heterogeneity, and the limited number of
treatment options drive the need for physiologically relevant assay platforms with human …
treatment options drive the need for physiologically relevant assay platforms with human …
Extracellular Matrix–Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival
SE Townsend, M Gannon - Endocrinology, 2019 - academic.oup.com
This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …
The role of the islet niche on beta cell structure and function
The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …
are complex microorgans embedded within the larger volume of the exocrine pancreas …
[HTML][HTML] Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications
Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells
DG Iworima, RK Baker, C Ellis, C Sherwood… - Stem Cell Research & …, 2024 - Springer
Background Diabetes is a disease affecting over 500 million people globally due to insulin
insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet …
insufficiency or insensitivity. For individuals with type 1 diabetes, pancreatic islet …
[HTML][HTML] In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors
Regeneration of injured human heart muscle is limited and an unmet clinical need. There
are no methods for the reproducible generation of clinical-quality stem cell-derived …
are no methods for the reproducible generation of clinical-quality stem cell-derived …
Laminins in metabolic tissues
A Goddi, L Schroedl, EM Brey, RN Cohen - Metabolism, 2021 - Elsevier
Laminins are extracellular matrix proteins that reside in the basement membrane and
provide structural support in addition to promoting cellular adhesion and migration. Through …
provide structural support in addition to promoting cellular adhesion and migration. Through …