In the clinical management of early-stage cutaneous melanoma, it is critical to determine
which patients are cured by surgery alone and which should be treated with adjuvant …

Integrin-beta 1 (ITGB1) is aberrantly overexpressed or downregulated in solid cancers;
however, its prognostic value remains controversial. Therefore, we conducted a meta …

A thorough updating of the best-selling, vital reference and textbook on melanocytic
proliferations PRAISE FOR THE FIRST EDITION:“Well-written and entertaining”—Modern …

The expression pattern of integrin-type cell adhesion receptors is often changed during
malignant transformation. In the present work, we studied the prognostic significance of β1 …

Many biological processes such as cell differentiation, cell migration or gene expression are
tightly controlled by cell–cell interactions or by various cytokines. During tumor progression …

Integrins are a family of transmembrane glycoprotein receptors that mediate cell-matrix and
cell-cell interactions. 1, 2 Integrins consist of an α and αβ subunits. To date 24 distinct …

Abstract Background and Objectives The objectives of this study were to investigate the role
of growth factors and matrix metalloproteinases in the brain metastasis. Methods Tumors …

The last two decades have seen spectacular advances in our understanding of the biology
of melanoma and, in particular, have elucidated the mechanisms operative in disease …

This review will briefly describe integrin function, address why integrins are attractive targets
for chemotherapeutic drug design, and discuss some ongoing studies aimed at inhibiting …

Preclinical and clinical findings indicate multiple tumour micro-environmental factors,
including growth factors, cytokines, cell-cell and cell-matrix adhesion molecules and …