Obesity II: establishing causal links between chemical exposures and obesity
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …
prevailing view is that obesity results from an imbalance between energy intake and …
Endocrine disruptors and obesity
JJ Heindel, R Newbold, TT Schug - Nature Reviews Endocrinology, 2015 - nature.com
The increasing incidence of obesity is a serious global public health challenge. Although the
obesity epidemic is largely fueled by poor nutrition and lack of exercise, certain chemicals …
obesity epidemic is largely fueled by poor nutrition and lack of exercise, certain chemicals …
Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta‐analysis of human studies
N Stratakis, S Rock, MA La Merrill, M Saez… - Obesity …, 2022 - Wiley Online Library
We conducted a systematic review and meta‐analysis of the associations between prenatal
exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on …
exposure to persistent organic pollutants (POPs) and childhood obesity. We focused on …
Toxicological function of adipose tissue: focus on persistent organic pollutants
M La Merrill, C Emond, MJ Kim… - Environmental …, 2013 - ehp.niehs.nih.gov
Background: Adipose tissue (AT) is involved in several physiological functions, including
metabolic regulation, energy storage, and endocrine functions. Objectives: In this review we …
metabolic regulation, energy storage, and endocrine functions. Objectives: In this review we …
Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation
LB Sales, JH Kamstra, PH Cenijn, LS Van Rijt… - Toxicology in vitro, 2013 - Elsevier
Recent studies suggest that endocrine disrupting chemicals (EDCs) may form a risk factor
for obesity by altering energy metabolism through epigenetic gene regulation. The goal of …
for obesity by altering energy metabolism through epigenetic gene regulation. The goal of …
Childhood obesity and environmental chemicals
M La Merrill, LS Birnbaum - Mount Sinai Journal of Medicine: a …, 2011 - Wiley Online Library
Childhood and adolescent rates of obesity and overweight are continuing to increase in
much of the world. Risk factors such as diet composition, excess caloric intake, decreased …
much of the world. Risk factors such as diet composition, excess caloric intake, decreased …
Associations between exposure to brominated flame retardants and metabolic syndrome and its components in US adults
Z Che, H Jia, R Chen, K Pan, Z Fan, C Su, Z Wu… - Science of The Total …, 2023 - Elsevier
Background Humans are simultaneously exposed to numerous of environmental
brominated flame retardants (BFRs). We aim to explore the overall associations of BFRs …
brominated flame retardants (BFRs). We aim to explore the overall associations of BFRs …
[HTML][HTML] The insulin-like growth factor system: A target for endocrine disruptors?
The insulin-like growth factor (IGF) system is a critical regulator of growth, especially during
fetal development, while also playing a central role in metabolic homeostasis. Endocrine …
fetal development, while also playing a central role in metabolic homeostasis. Endocrine …
Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47
JH Kamstra, E Hruba, B Blumberg… - … science & technology, 2014 - ACS Publications
Recent studies suggest that exposure to endocrine-disrupting compounds (EDCs) may play
a role in the development of obesity. EDCs such as the flame retardant 2, 2′, 4, 4 …
a role in the development of obesity. EDCs such as the flame retardant 2, 2′, 4, 4 …
In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis
In this study, we investigated the effects of in utero and lactational exposure to BDE-47 on
the progression of obesity and metabolic dysfunction in a diet-induced obesity model …
the progression of obesity and metabolic dysfunction in a diet-induced obesity model …