Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons
and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to …

Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …

A hallmark of schizophrenia pathophysiology is the dysfunction of cortical inhibitory GABA
neurons expressing parvalbumin, which are essential for coordinating neuronal synchrony …

The positioning of lysosomes within the cytoplasm is emerging as a critical determinant of
many lysosomal functions. Here we report the identification of a multisubunit complex …

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

BACKGROUND: A hallmark of the pathophysiology of schizophrenia is a dysfunction of
parvalbumin-expressing fast-spiking interneurons, which are essential for the coordination …

Melanins, the main pigments of the skin and hair in mammals, are synthesized within
membrane-bound organelles of melanocytes called melanosomes. Melanosome structure …

Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and
schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics …