International cancer registries make real-world genomic and clinical data available, but their
joint analysis remains a challenge. AACR Project GENIE, an international cancer registry …

Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

Drug resistance causes catastrophic cancer treatment failures. Mutations in target proteins
with altered drug binding indicate a main mechanism of cancer drug resistance (CDR) …

The innate immune response contributes to the development or attenuation of acute and
chronic diseases, including cancer. Microbial DNA and mislocalized DNA from damaged …

Abstract MarkerDB (https://markerdb. ca) has become a leading resource for comprehensive
information on molecular biomarkers. Over the past 3 years, the database has evolved …

Relapse is one of the major challenges in clinical treatment of acute myeloid leukemia
(AML). Though minimal residual disease (MRD) monitoring plays a crucial role in …

Background Although the clinical application of PARP inhibitors has brought hope to ovarian
cancer, the problem of its resistance has become increasingly prominent. Therefore, clinical …

Background Tumor-specific mutated proteins can create immunogenic non-self, mutation-
containing 'neoepitopes' that are attractive targets for adoptive T-cell therapies. To avoid the …

Many molecular alterations serve as clinically prognostic or therapy-predictive biomarkers,
typically detected using single or multi-gene molecular assays. However, these assays are …

Next-generation sequencing methods continuously provide clinicians and researchers in
precision oncology with growing numbers of genomic variants found in cancer. However …