It has become increasingly difficult to find an area of cell biology in which lipids do not have
important, if not key, roles as signalling and regulatory molecules. The rapidly expanding …

Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural
roles in cellular membranes, some metabolites, including ceramide, sphingosine, and …

Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated,
acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or …

Recently the sphingomyelin cycle, involving the hydrolysis of membrane sphingomyelin by
an activated sphingomyelinase to generate ceramide, has emerged as a key pathway in cell …

Gangliosides are known as modulators of transmembrane signaling by regulating various
receptor functions. We have found that insulin resistance induced by tumor necrosis factor-α …

Glycolipids such as ganglioside GM1 are involved in the building of carbohydrate layers on
the surface of living cells. The investigation of the metabolism of this class of compounds …

Gangliosides participate in development and tissue differentiation. Cross-linking of the
apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor …

Glycosylphosphatidylinositol (GPI)-anchored proteins participate in many cell surface
functions; however, the molecular associations of these lipid-linked proteins within the …

Sphingolipids and their metabolic products are now known to have second-messenger
functions in a variety of cellular signaling pathways. Lactosylceramide (LacCer), a …

The therapeutic options for lysosomal storage diseases (LSDs) have expanded greatly over
the past decade, although for many disorders there is still no effective treatment. Given that …