We propose a weight-neutral strategy for obesity treatment on the following grounds:(1) the
mortality risk associated with obesity is largely attenuated or eliminated by moderate-to-high …

Metabolic adaptation to weight changes relates to body weight control, obesity and
malnutrition. Adaptive thermogenesis (AT) refers to changes in resting and non-resting …

Objective To measure long‐term changes in resting metabolic rate (RMR) and body
composition in participants of “The Biggest Loser” competition. Methods Body composition …

Although many persons with obesity can lose weight by lifestyle (diet and physical activity)
therapy, successful long‐term weight loss is difficult to achieve, and most people who lose …

Traditional diagnosis and understanding of the pathophysiology of obesity are based on
excessive fat storage due to a chronically positive energy balance characterized by body …

Calorie restriction (CR) is the most potent, non-pharmacological intervention to support
metabolic health. The effects of calorie restriction exceed weight loss. Consistent throughout …

BMI is widely used as a measure of weight status and disease risks; it defines overweight
and obesity based on statistical criteria. BMI is a score; neither is it biologically sound nor …

Whether dieting makes people fatter has been a subject of considerable controversy over
the past 30 years. More recent analysis of several prospective studies suggest, however …

'The great enemy of truth is very often not the lie—deliberate, contrived and dishonest—but
the myth—persistent, persuasive and unrealistic. Too often we hold fast to the cliches of our …

Although reduced skeletal muscle mass is a major predictor of impaired physical function
and survival, it remains inconsistently diagnosed to a lack of standardized diagnostic …