DNA damage can alter nucleotide sequences and lead to expression of dysfunctional
proteins that impact normal cellular physiology. Sources of DNA damage can be …

DNA damage repair deficiency leads to the increased risk of genome instability and
oncogenic transformation. In the meanwhile, this deficiency could be exploited for cancer …

Background BRCA1 or BRCA2-mutated breast cancers are sensitive to poly (ADP-ribose)
polymerase (PARP) inhibitors and platinum agents owing to deficiency in homologous …

ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad
functions, including roles in stress responses elicited, for example, by DNA damage and …

Identification of targeted therapies for TNBC is an urgent medical need. Using a drug
combination screen reliant on synthetic lethal interactions, we identified clinically relevant …

DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and
how broken DNA is prevented from separating is not understood. Here we uncover that the …

It is being increasingly appreciated that the immunomodulatory functions of PARP1
inhibitors (PARPi) underlie their clinical activities in various BRCA-mutated tumors. PARPi …

PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether
specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in …

The immunogenicity of a cancer cell is derived from accumulated somatic mutations.
However, on the contrary to increased immunogenicity, anti-cancer immune response tends …

Breast and ovarian cancers are some of the most common tumors in females, and the
genetic predisposition is emerging as one of the key risk factors in the development of these …