Advancing therapeutics for recurrent clostridioides difficile infections: an overview of vowst's FDA approval and implications

N Jain, TP Umar, AF Fahner, V Gibietis - Gut Microbes, 2023 - Taylor & Francis
Clostridioides difficile infections (CDI) are a leading cause of healthcare-associated
infections with a high relapse rate. Current treatment guidelines recommend fidaxomicin as …

Microbiome-Related and Infection Control Approaches to Primary and Secondary Prevention of Clostridioides difficile Infections

LV McFarland, EJC Goldstein, R Kullar - Microorganisms, 2023 - mdpi.com
Clostridioides difficile infections (CDIs) have decreased in the past years, but since 2021,
some hospitals have reported an increase in CDI rates. CDI remains a global concern and …

Microbiota-Based Live Biotherapeutic Products for Clostridioides Difficile Infection- The Devil is in the Details

L Monday, G Tillotson, T Chopra - Infection and Drug Resistance, 2024 - Taylor & Francis
Clostridioides difficile infection (CDI) remains a significant contributor to healthcare costs
and morbidity due to high rates of recurrence. Currently, available antibiotic treatment …

RBX2660 (REBYOTA®) in preventing recurrence of Clostridioides difficile infection: a profile of its use in the USA

HA Blair - Drugs & Therapy Perspectives, 2023 - Springer
Abstract RBX2660 (fecal microbiota, live-jslm; REBYOTA®) is an emerging option for the
prevention of recurrent Clostridioides difficile infection (CDI) following standard of care …

PhosphoLipidome Alteration Induced by Clostridioides difficile Toxin B in Enteric Glial Cells

S Buratta, L Urbanelli, RM Pellegrino, HBR Alabed… - Cells, 2024 - mdpi.com
Clostridioides difficile (C. difficile) is responsible for a spectrum of nosocomial/antibiotic-
associated gastrointestinal diseases that are increasing in global incidence and mortality …

Alternative treatment of recurrent Clostridioides difficile infection in adults by fecal transplantation: an overview of phase I–IV studies from Clinicaltrials.gov

NA Obaid - Frontiers in Microbiology, 2024 - frontiersin.org
Background Fecal microbiota transplantation (FMT) is an interventional approach to treat
chronic and recurrent Clostridioides difficile infection (CDI). However, there is insufficient …

In-vitro determination of inhibitory effects of probiotic strains on Clostridioides difficile

GT Yalçin, MN Tosun, NND Zorba - Anaerobe, 2023 - Elsevier
Commercial probiotic strains inhibited C. difficile, and other Clostridium cultures with zones
14.2–78.9 mm. The highest inhibition was observed with commercial culture on C. difficile …

The conundrum of bacteria-specific antibiotics

S Datta - Journal of Antimicrobial Chemotherapy, 2023 - academic.oup.com
There is a continual debate on the pros and cons of broad-spectrum versus pathogen-
specific antibiotics. The unmet need for a solution for antimicrobial resistance (AMR) has put …

Modulating gut microbiota for treating antibiotic-associated diarrhea from Clostridium difficile infection: insights from Lizhong decoction and its polysaccharide …

XQ Rong, QL Shu - Letters in Applied Microbiology, 2024 - academic.oup.com
To investigate whether the polysaccharide component of the Traditional Chinese Medicine
(TCM) formula Lizhong decoction (LZD) has therapeutic effects and regulates gut microbiota …

[HTML][HTML] Therapeutics involved in managing initial and recurrent Clostridium difficile infection: An updated literature review

VK Nagesh, HHV Tran, D Elias… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Clostridium difficile infection (CDI) has been increasing due to the effect of recurrent
hospitalizations. The use of antibiotics has been shown to alter the gut microbiome and lead …