From synapses to circuits, astrocytes regulate behavior

KA Lyon, NJ Allen - Frontiers in neural circuits, 2022 - frontiersin.org
Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience

J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Side-by-side comparison of the effects of Gq-and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the …

Y Van Den Herrewegen, TM Sanderson, S Sahu… - Molecular Brain, 2021 - Springer
Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for
shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient …

Astrocyte structural heterogeneity in the mouse hippocampus

JF Viana, JL Machado, DS Abreu, A Veiga, S Barsanti… - Glia, 2023 - Wiley Online Library
Astrocytes are integral components of brain circuits, where they sense, process, and
respond to surrounding activity, maintaining homeostasis and regulating synaptic …

Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

M Akter, M Hasan, AS Ramkrishnan, Z Iqbal, X Zheng… - Elife, 2023 - elifesciences.org
Astrocyte-derived L-lactate was shown to confer beneficial effects on synaptic plasticity and
cognitive functions. However, how astrocytic G i signaling in the anterior cingulate cortex …

Know thy SEFL: Fear sensitization and its relevance to stressor-related disorders

KJ Nishimura, AM Poulos, MR Drew… - … & Biobehavioral Reviews, 2022 - Elsevier
Extreme stress can cause long-lasting changes in affective behavior manifesting in
conditions such as post-traumatic stress disorder (PTSD). Understanding the biological …

Role of hydrogen sulfide and polysulfides in neurological diseases: focus on protein S-persulfidation

HJ Sun, ZY Wu, XW Nie, JS Bian - Current …, 2021 - ingentaconnect.com
Hydrogen sulfide (H2S) and hydrogen polysulfides are recognized as important signaling
molecules that are generated physiologically in the body, including the central nervous …

Stress‐induced structural and functional modifications of astrocytes—Further implicating glia in the central response to stress

C Murphy‐Royal, GR Gordon, JS Bains - Glia, 2019 - Wiley Online Library
An organism's response to stress requires activation of multiple brain regions. This can have
long‐lasting effects on synaptic transmission and plasticity that likely provide adaptive …

[HTML][HTML] Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1→ ACC projection to engrams

R Refaeli, T Kreisel, TR Yaish, M Groysman, I Goshen - Cell Reports, 2024 - cell.com
The maturation of engrams from recent to remote time points involves the recruitment of CA1
neurons projecting to the anterior cingulate cortex (CA1→ ACC). Modifications of G-protein …

Macro-and microscale stress–associated alterations in brain structure: Translational link with depression

M Banasr, G Sanacora, I Esterlis - Biological Psychiatry, 2021 - Elsevier
Major depressive disorder (MDD) is a stress-related disorder associated with many
cytoarchitectural and neurochemical changes. However, the majority of these changes …