Beyond a neurotransmitter: The role of serotonin in inflammation and immunity

H Wu, TH Denna, JN Storkersen, VA Gerriets - Pharmacological research, 2019 - Elsevier
Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

Serotonergic mechanisms regulating the GI tract: experimental evidence and therapeutic relevance

N Terry, KG Margolis - Gastrointestinal Pharmacology, 2017 - Springer
Abstract Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical
for central nervous system (CNS) development and function. 95% of the body's serotonin …

Immunomodulatory effects mediated by serotonin

R Arreola, E Becerril-Villanueva… - Journal of …, 2015 - Wiley Online Library
Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

Nanotools for neuroscience and brain activity mapping

AP Alivisatos, AM Andrews, ES Boyden, M Chun… - ACS …, 2013 - ACS Publications
Neuroscience is at a crossroads. Great effort is being invested into deciphering specific
neural interactions and circuits. At the same time, there exist few general theories or …

DAT and TH expression marks human Parkinson's disease in peripheral immune cells

A Gopinath, P Mackie, B Hashimi, AM Buchanan… - npj Parkinson's …, 2022 - nature.com
Parkinson's disease (PD) is marked by a loss of dopamine neurons, decreased dopamine
transporter (DAT) and tyrosine hydroxylase (TH) expression. However, this validation …

Enteric neuronal regulation of intestinal inflammation

KG Margolis, MD Gershon - Trends in neurosciences, 2016 - cell.com
Recent research has highlighted the importance of the two-way interaction between the
nervous and immune systems. This interaction is particularly important in the bowel because …

An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish

MD McDonald - Comparative Biochemistry and Physiology Part C …, 2017 - Elsevier
Pharmaceuticals and personal care products (PPCPs) are found in measureable quantities
within the aquatic environment. Selective serotonin reuptake inhibitor (SSRI) …

Immune system activation and depression: roles of serotonin in the central nervous system and periphery

MJ Robson, MA Quinlan… - ACS chemical …, 2017 - ACS Publications
Serotonin (5-hydroxytryptamine, 5-HT) has long been recognized as a key contributor to the
regulation of mood and anxiety and is strongly associated with the etiology of major …

[HTML][HTML] Serotonergic control of gastrointestinal development, motility, and inflammation

SA Najjar, LY Hung, KG Margolis - Comprehensive Physiology, 2023 - ncbi.nlm.nih.gov
Although it is most well-known for its roles in central nervous system (CNS) function, the vast
majority of serotonin, or 5-hydroxytryptamine (5-HT), is produced in the gastrointestinal (GI) …

Evidence for PMAT- and OCT-like biogenic amine transporters in a probiotic strain of Lactobacillus: Implications for interkingdom communication within the microbiota …

M Lyte, DR Brown - PLoS One, 2018 - journals.plos.org
The ability of prokaryotic microbes to produce and respond to neurochemicals that are more
often associated with eukaryotic systems is increasingly recognized through the concept of …