TERRA is a class of telomeric repeat-containing RNAs that are expressed from telomeres in
multiple organisms. TERRA transcripts play key roles in telomere maintenance and their …

In recent years, significant advances have been made in understanding the intricate details
of the mechanisms underlying alternative lengthening of telomeres (ALT). Studies of a …

Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …

The function of TERRA in the regulation of telomerase in human cells is still debated. While
TERRA interacts with telomerase, how it regulates telomerase function remains unknown …

R-loops are three-stranded structures that can pose threats to genome stability. RNase H1
precisely recognizes R-loops to drive their resolution within the genome, but the underlying …

Inactivating mutations in chromatin modifiers, like the α-thalassemia/mental retardation, X-
linked (ATRX)-death domain-associated protein (DAXX) chromatin remodeling/histone H3. 3 …

Transcription-replication conflict is a major cause of replication stress that arises when
replication forks collide with the transcription machinery. Replication fork stalling at sites of …

R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

Simple Summary R-loops, also referred to as RNA: DNA hybrids, are tripartite structures
formed when a single-stranded RNA molecule forms a complex with a double-stranded DNA …

The telomeric noncoding RNA TERRA is a key component of telomeres and it is widely
expressed in normal as well as cancer cells. In the last 15 years, several publications have …