Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—
relapsing-remitting, secondary progressive, and primary progressive—for patient care …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Microglia originate from myeloid progenitors in the embryonic yolk sac and play an integral
role in central nervous system (CNS) development, immune surveillance and repair. The …

Background: Chronic lesion activity driven by smoldering inflammation is a pathological
hallmark of progressive forms of multiple sclerosis (MS). Objective: To develop a method for …

Chronic active multiple sclerosis lesions, characterized by a hyperintense rim of iron-
enriched, activated microglia and macrophages, have been linked to greater tissue damage …

Chronic active lesions (CAL) are an important manifestation of chronic inflammation in
multiple sclerosis (MS) and have implications for non-relapsing biological progression. In …

Microglia in multiple sclerosis – pathogenesis and imaging : Current Opinion in Neurology
Microglia in multiple sclerosis – pathogenesis and imaging : Current Opinion in Neurology Log …

Objective Slowly expanding lesions (SELs), a subgroup of chronic white matter lesions that
gradually expand over time, have been shown to predict disability accumulation in primary …

Understanding the mechanisms underlying progression in multiple sclerosis (MS) is one of
the key elements contributing to the identification of appropriate therapeutic targets for this …

Background and Objectives Our aim was to investigate whether 18-kDa translocator protein
(TSPO) radioligand binding in gray matter (GM) predicts later disability progression in …