Cutaneous wound healing ultimately functions to facilitate barrier restoration following injury-
induced loss of skin integrity. It is an evolutionarily conserved, multi-cellular, multi-molecular …

The term 'matricellular'has been applied to a group of extracellular proteins that do not
contribute directly to the formation of structural elements in vertebrates but serve to modulate …

Aging is considered to be the major risk factor for the development of atherosclerosis and,
therefore, for coronary artery disease. Apart from age-associated remodeling of the vascular …

Diabetic retinopathy continues to be the leading cause of legal blindness among working-
age individuals. The earliest histological features of diabetic retinopathy include neuroretinal …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

During angiogenesis, endothelial cell growth, migration, and tube formation are regulated by
pro-and anti-angiogenic factors, matrix-degrading proteases, and cell–extracellular matrix …

Thrombospondins (TSPs) 1 and 2 are matricellular proteins with the well-characterized
ability to inhibit angiogenesis in vivo, and the migration and proliferation of cultured …

Abstract Thrombospondins (TSPs)-1 and-2 were among the first protein inhibitors of
angiogenesis to be identified, a property that was subsequently attributed to the interactions …

Thrombospondins (TSPs) 1 and 2 are extracellular modular glycoproteins that are best
known for their anti-angiogenic properties and their ability to modulate cell–matrix …

Abstract Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular
matrix (ECM), which serve a significant role in the pathological processes of various …