Cerebral cavernous malformations (CCM) are manifested by microvascular lesions
characterized by leaky endothelial cells with minimal intervening parenchyma …

Cerebral cavernous malformations (CCMs) are common inherited and sporadic vascular
malformations that cause strokes and seizures in younger individuals. CCMs arise from …

Cerebral cavernous malformations (CCMs) are neurovascular abnormalities characterized
by thin, leaky blood vessels resulting in lesions that predispose to haemorrhages, stroke …

Abstract Cerebral cavernous malformations 2 (CCM2) loss is associated with the familial
form of CCM disease. The protein kinase MEKK3 (MAP3K3) is essential for embryonic …

Linking variants from genome-wide association studies (GWAS) to underlying mechanisms
of disease remains a challenge,–. For some diseases, a successful strategy has been to …

The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-
related gene, although it is now usually known as CCM3, as the third causative gene of …

We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-
bundling protein in vitro. Here, we report that TLNRD1 is expressed in the vasculature in …

Cerebral cavernous malformations (CCMs) are low-flow, hemorrhagic vascular lesions of
the central nervous system of genetic origin, which can cause stroke-like symptoms and …

Mutations in the essential adaptor proteins CCM2 or CCM3 lead to cerebral cavernous
malformations (CCM), vascular lesions that most frequently occur in the brain and are …

The disease known as cerebral cavernous malformations mostly occurs in the central
nervous system, and their typical histological presentations are multiple lumen formation …