Mitochondria are intracellular organelles involved in energy production, cell metabolism and
cell signaling. They are essential not only in the process of ATP synthesis, lipid metabolism …

Since 1985, the thiazolidinedione pioglitazone has been widely used as an insulin
sensitizer drug for type 2 diabetes mellitus (T2DM). Although fluid retention was early …

Pulmonary hypertension (PH) is a feature of a variety of diseases and continues to harbor
high morbidity and mortality. The main consequence of PH is right-sided heart failure which …

Numerous studies found intestinal microbiota alterations which are thought to affect the
development of various diseases through the production of gut-derived metabolites …

Acute kidney injury (AKI) is a life-threatening condition that is one of most common side
effects of cisplatin therapy. Fatty acid oxidation (FAO) is the main source of energy …

Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …

Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV)
function and survival than men; however, the underlying mechanisms are unknown. We …

Cardiovascular diseases remain the leading cause of death worldwide in the last decade,
accompanied by immense health and economic burdens. Heart failure (HF), as the terminal …

Obesity is a prevalent global public health issue characterized by excess body fat. Adipose
tissue is now recognized as an important endocrine organ releasing an abundance of …

Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and
function. It is becoming increasingly clear that endothelial cell dysfunction significantly …