Drug resistance and tolerance in fungi

J Berman, DJ Krysan - Nature Reviews Microbiology, 2020 - nature.com
Systemic fungal infections pose a serious clinical problem. Treatment options are limited,
and antifungal drug resistance is increasing. In addition, a substantial proportion of patients …

[HTML][HTML] Invasive candidiasis

PG Pappas, MS Lionakis, MC Arendrup… - Nature Reviews …, 2018 - nature.com
Invasive candidiasis is an important health-care-associated fungal infection that can be
caused by several Candida spp.; the most common species is Candida albicans, but the …

The global problem of antifungal resistance: prevalence, mechanisms, and management

DS Perlin, R Rautemaa-Richardson… - The Lancet infectious …, 2017 - thelancet.com
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …

Emerging threats in antifungal-resistant fungal pathogens

D Sanglard - Frontiers in medicine, 2016 - frontiersin.org
The use of antifungal drugs in the therapy of fungal diseases can lead to the development of
antifungal resistance. Resistance has been described for virtually all antifungal agents in …

[HTML][HTML] Using inorganic nanoparticles to fight fungal infections in the antimicrobial resistant era

T Huang, X Li, M Maier, NM O'Brien-Simpson… - Acta Biomaterialia, 2023 - Elsevier
Fungal infections pose a serious threat to human health and livelihoods. The number and
variety of clinically approved antifungal drugs is very limited, and the emergence and rapid …

Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

Candidemia and invasive candidiasis in adults: A narrative review

S Antinori, L Milazzo, S Sollima, M Galli… - European journal of …, 2016 - Elsevier
Candidemia and invasive candidiasis are major causes of morbidity and mortality, and their
incidence is increasing because of the growing complexity of patients. Five species of …

Mechanisms of echinocandin antifungal drug resistance

DS Perlin - Annals of the new York Academy of Sciences, 2015 - Wiley Online Library
Fungal infections due to Candida and Aspergillus species cause extensive morbidity and
mortality, especially among immunosuppressed patients, and antifungal therapy is critical to …

Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance

KR Healey, Y Zhao, WB Perez, SR Lockhart… - Nature …, 2016 - nature.com
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily
acquires resistance to multiple drug classes, including triazoles and/or echinocandins. Thus …

Emerging multidrug-resistant Candida species

AL Colombo, JN de Almeida Júnior… - Current Opinion in …, 2017 - journals.lww.com
We checked all papers published along the last 10 years describing epidemiological,
diagnostic, and clinical aspects of infections by MDR Candida spp., with emphasis on C …