Phase separation as a new form of regulation in innate immunity

L Wang, W Zhou - Molecular Cell, 2024 - cell.com
Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The
innate immune system encodes many sensor, adaptor, and effector proteins and relies on …

[HTML][HTML] Recent advances in understanding TCR signaling: a synaptic perspective

ML Dustin - Faculty Reviews, 2023 - ncbi.nlm.nih.gov
The T cell receptor is a multi-subunit complex that carries out a range of recognition tasks for
multiple lymphocyte types and translates recognition into signals that regulate survival …

Domain-Targeted Membrane Partitioning of Specific Proteins with DNA Nanodevices

YH Ma, Y Zhu, H Wu, Y He, Q Zhang… - Journal of the …, 2024 - ACS Publications
The cell membrane exhibits a remarkable complexity of lipids and proteins that dynamically
segregate into distinct domains to coordinate various cellular functions. The ability to …

[HTML][HTML] EphA2 as a phase separation protein associated with ferroptosis and immune cell infiltration in colorectal cancer

Y Li, Q Peng, L Wang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Colorectal cancer is one of the most common malignant tumors in the digestive system, and
its high incidence and metastasis rate make it a terrible killer that threatens human health. In …

Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity

Z Ren, K Wang, Y Zhang, H Chen, Y Zhu, H Li… - Cell Chemical …, 2024 - cell.com
T cell receptor (TCR) plays a fundamental role in adaptive immunity, and TCR-T cell therapy
holds great promise for treating solid tumors and other diseases. However, there is a …