Phase separation as a new form of regulation in innate immunity
Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The
innate immune system encodes many sensor, adaptor, and effector proteins and relies on …
innate immune system encodes many sensor, adaptor, and effector proteins and relies on …
[HTML][HTML] Recent advances in understanding TCR signaling: a synaptic perspective
ML Dustin - Faculty Reviews, 2023 - ncbi.nlm.nih.gov
The T cell receptor is a multi-subunit complex that carries out a range of recognition tasks for
multiple lymphocyte types and translates recognition into signals that regulate survival …
multiple lymphocyte types and translates recognition into signals that regulate survival …
Domain-Targeted Membrane Partitioning of Specific Proteins with DNA Nanodevices
YH Ma, Y Zhu, H Wu, Y He, Q Zhang… - Journal of the …, 2024 - ACS Publications
The cell membrane exhibits a remarkable complexity of lipids and proteins that dynamically
segregate into distinct domains to coordinate various cellular functions. The ability to …
segregate into distinct domains to coordinate various cellular functions. The ability to …
[HTML][HTML] EphA2 as a phase separation protein associated with ferroptosis and immune cell infiltration in colorectal cancer
Y Li, Q Peng, L Wang - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Colorectal cancer is one of the most common malignant tumors in the digestive system, and
its high incidence and metastasis rate make it a terrible killer that threatens human health. In …
its high incidence and metastasis rate make it a terrible killer that threatens human health. In …
Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
Z Ren, K Wang, Y Zhang, H Chen, Y Zhu, H Li… - Cell Chemical …, 2024 - cell.com
T cell receptor (TCR) plays a fundamental role in adaptive immunity, and TCR-T cell therapy
holds great promise for treating solid tumors and other diseases. However, there is a …
holds great promise for treating solid tumors and other diseases. However, there is a …