Abstract The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat
to human society in terms of health, economy, and lifestyle. Although the virus usually first …

The first report demonstrating that prolonged endurance exercise promotes oxidative stress
in humans was published more than 4 decades ago. Since this discovery, many ensuing …

The contractile activity, high oxygen consumption and metabolic rate of skeletal muscle
cause it to continuously produce moderate levels of oxidant species, such as reactive …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

The existence of free radicals in living cells was first reported in 1954 and this important
finding helped launch the field of free radical biology. However, the discovery that muscular …

Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …

Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes,
cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the …

Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …

A decline in energy is common in aging, and the restoration of mitochondrial bioenergetics
may offer a common approach for the treatment of numerous age‐associated diseases …