Oxalate homeostasis is maintained through a delicate balance between endogenous
sources, exogenous supply and excretion from the body. Novel studies have shed light on …

Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers
and anion channels transporting a broad range of substrates, including Cl−, HCO3−, sulfate …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

The epithelial anion transporter SLC26A9 contributes to airway surface hydration and
gastric acid production. Colocalizing with CFTR, SLC26A9 has been proposed as a target …

Airway mucus obstruction is a hallmark of many chronic lung diseases including rare genetic
disorders such as cystic fibrosis (CF) and primary ciliary dyskinesia, as well as common lung …

The ten-member SLC26 gene family encodes anion exchangers capable of transporting a
wide variety of monovalent and divalent anions. The physiological role (s) of individual …

Chloride absorption and bicarbonate secretion are vital functions of epithelia,,,,,, as
highlighted by cystic fibrosis and diseases associated with mutations in members of the …