Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of
endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic …

Cyclophosphamide is an alkylating agent belonging to the group of oxazaphosporines. As
cyclophosphamide is in clinical use for more than 40 years, there is a lot of experience using …

The ability to direct the differentiation of human pluripotent stem cells (hPSCs) to the different
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …

Cyclophosphamide remains one of the most successful and widely utilized antineoplastic
drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used …

We evaluated the safety and efficacy of high-dose, posttransplantation cyclophosphamide
(Cy) to prevent graft rejection and graft-versus-host disease (GVHD) after outpatient …

The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages
known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior …

Although the concept that cancers originate from stem cells (SC) is becoming scientifically
accepted, mechanisms by which SC contribute to tumor initiation and progression are …

High-dose, posttransplantation cyclophosphamide (PTCy) is an effective strategy for
preventing graft-versus-host disease (GVHD) after allogeneic blood or marrow …

Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus
providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress …