Harnessing big data to advance treatment and understanding of pulmonary hypertension

CJ Rhodes, AJ Sweatt, BA Maron - Circulation research, 2022 - Am Heart Assoc
Pulmonary hypertension is a complex disease with multiple causes, corresponding to
phenotypic heterogeneity and variable therapeutic responses. Advancing understanding of …

Pulmonary hypertension: a contemporary review

S Johnson, N Sommer, K Cox-Flaherty… - American Journal of …, 2023 - atsjournals.org
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH)
associated with lung disease, and chronic thromboembolic PH cast new light on the …

Studying molecular interactions via capillary electrophoresis and microscale thermophoresis: A review

M Asmari, L Michalcová, AE Ibrahim, Z Glatz… - …, 2023 - Wiley Online Library
The process of choosing the most proper technique for studying the molecular interactions is
based on critical factors such as instrumentation complexity, automation, experimental …

[HTML][HTML] Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

Y Ye, Q Xu, T Wuren - Frontiers in Immunology, 2023 - frontiersin.org
Hypoxic pulmonary hypertension (HPH) is a complicated vascular disorder characterized by
diverse mechanisms that lead to elevated blood pressure in pulmonary circulation. Recent …

Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS‐CoV‐2 infection

GA Alba, AO Samokhin, RS Wang… - Pulmonary …, 2022 - Wiley Online Library
The pathobiology of in situ pulmonary thrombosis in acute respiratory distress syndrome
(ARDS) due to severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is …

Human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension

G Hansmann, P Chouvarine, F Diekmann… - Nature Cardiovascular …, 2022 - nature.com
Here we report application of human umbilical cord mesenchymal stem cell (HUCMSC)-
derived therapy for pulmonary arterial hypertension (PAH). A 3-year-old female presented …

Evidence of advanced pulmonary vascular remodeling in obstructive hypertrophic cardiomyopathy with pulmonary hypertension

BA Maron, DE Kleiner, E Arons, BM Wertheim… - Chest, 2023 - Elsevier
Background Elevated mean pulmonary artery pressure (mPAP) is common in patients with
hypertrophic cardiomyopathy (HCM) and heart failure symptoms. However, dynamic left …

Chronic thromboembolic pulmonary hypertension: the bench

GA Alba, D Atri, S Darbha, I Singh, VF Tapson… - Current Cardiology …, 2021 - Springer
Abstract Purpose of Review Chronic thromboembolic pulmonary hypertension (CTEPH) is
an uncommon complication of acute pulmonary embolism (PE), in which the red, platelet …

Plasma NEDD9 is increased following SARS‐CoV‐2 infection and associates with indices of pulmonary vascular dysfunction

GA Alba, IY Zhou, M Mascia, M Magaletta… - Pulmonary …, 2024 - Wiley Online Library
Compared to healthy volunteers, participants with post‐acute sequelae of SARS‐CoV‐2
infection (PASC) demonstrated increased plasma levels of the prothrombotic protein …

Transcriptome analysis reveals differential gene expression between the closing ductus arteriosus and the patent ductus arteriosus in humans

J Saito, T Kojima, S Tanifuji, Y Kato, S Oka… - Journal of …, 2021 - mdpi.com
The ductus arteriosus (DA) immediately starts closing after birth. This dynamic process
involves DA-specific properties, including highly differentiated smooth muscle, sparse elastic …