Drug of abuse (DOA) consumption is a growing problem worldwide, particularly with
increasing numbers of new psychoactive substances (NPS) entering the drug market …

Opium poppy has important medical, socioeconomic, forensic and political implications.
More than 80 benzylisoquinoline alkaloids have been described, many of them with relevant …

Tramadol and tapentadol are centrally acting, synthetic opioid analgesics used in the
treatment of moderate to severe pain. Main metabolic patterns for these drugs in humans are …

Background Rectal cancer is one of the most prevalent tumor types. Understanding the
metabolic profile of rectal cancer is important for developing therapeutic approaches and …

Metabolomics has been widely applied to toxicological fields, especially to elucidate the
mechanism of action of toxicity. In this review, metabolomics application with focus on the …

Background Gastric cancer is the fourth most common cancer and the second most deadly
cancer worldwide. Study on molecular mechanisms of carcinogenesis will play a significant …

Introduction NMR metabolomics is increasingly used in forensics, due to the possibility of
investigating both endogenous metabolic profiles and exogenous molecules that may help …

Background The biomarker identification of human esophageal cancer is critical for its early
diagnosis and therapeutic approaches that will significantly improve patient survival …

Despite the progress in characterising the pharmacological profile of drugs of abuse, their
precise biochemical impact remains unclear. The metabolome reflects the multifaceted …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …