NADH: quinone oxidoreductase (complex I) pumps protons across the inner membrane of
mitochondria or the plasma membrane of many bacteria. Human complex I is involved in …

Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to
generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry …

Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that
results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in …

Increasing attention has focused on the significance of RNA in sperm, in light of its
contribution to the birth and long-term health of a child, role in sperm function and diagnostic …

Virtually every mammalian cell contains mitochondria. These double-membrane organelles
continuously change shape and position and contain the complete metabolic machinery for …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown
cause with a median survival of only three years. Little is known about the mechanisms that …

Among many anticancer drugs collectively named “targeted or molecular therapies”
epigenetic drugs are clearly promising. Differently from other agents targeting a single gene …

The HtrA family refers to a group of related oligomeric serine proteases that combine a
trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode …

We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial
quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality …

The signal transducer and activator of transcription 3 (STAT3), a nuclear transcription factor,
is also present in mitochondria and regulates cellular respiration in a transcriptional …