Quantum mechanical studies on the photophysics and the photochemistry of nucleic acids and nucleobases

R Improta, F Santoro, L Blancafort - Chemical reviews, 2016 - ACS Publications
The photophysics and photochemistry of DNA is of great importance due to the potential
damage of the genetic code by UV light. Quantum mechanical studies have played a key …

Photoprotection: extending lessons learned from studying natural sunscreens to the design of artificial sunscreen constituents

LA Baker, B Marchetti, TNV Karsili… - Chemical Society …, 2017 - pubs.rsc.org
Evolution has ensured that plants and animals have developed effective protection
mechanisms against the potentially harmful effects of incident ultraviolet radiation (UVR) …

Nucleic acids as a playground for the computational study of the photophysics and photochemistry of multichromophore assemblies

L Martínez Fernández, F Santoro… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus The interaction between light and multichromophoric assemblies (MCAs) is the
primary event of many fundamental processes, from photosynthesis to organic photovoltaics …

Life in the light: nucleic acid photoproperties as a legacy of chemical evolution

AA Beckstead, Y Zhang, MS de Vries… - Physical Chemistry …, 2016 - pubs.rsc.org
Photophysical investigations of the canonical nucleobases that make up DNA and RNA
during the past 15 years have revealed that excited states formed by the absorption of UV …

Quantum chemical modeling of the photoinduced activity of multichromophoric biosystems: focus review

F Segatta, L Cupellini, M Garavelli… - Chemical reviews, 2019 - ACS Publications
Multichromophoric biosystems represent a broad family with very diverse members, ranging
from light-harvesting pigment–protein complexes to nucleic acids. The former are designed …

UV‐induced DNA damage: the role of electronic excited states

D Markovitsi - Photochemistry and photobiology, 2016 - Wiley Online Library
The knowledge of the fundamental processes induced by the direct absorption of UV
radiation by DNA allows extrapolating conclusions drawn from in vitro studies to the in‐vivo …

Ultrafast Formation of a Delocalized Triplet-Excited State in an Epigenetically Modified DNA Duplex under Direct UV Excitation

X Wang, L Martínez-Fernández, Y Zhang… - Journal of the …, 2024 - ACS Publications
Epigenetic modifications impart important functionality to nucleic acids during gene
expression but may increase the risk of photoinduced gene mutations. Thus, it is crucial to …

Hydrogen bonding in natural and unnatural base pairs—a local vibrational mode study

N Beiranvand, M Freindorf, E Kraka - Molecules, 2021 - mdpi.com
In this work hydrogen bonding in a diverse set of 36 unnatural and the three natural Watson
Crick base pairs adenine (A)–thymine (T), adenine (A)–uracil (U) and guanine (G)–cytosine …

Adenine radical cation formation by a ligand-centered excited state of an intercalated chromium polypyridyl complex leads to enhanced DNA photo-oxidation

FA Baptista, D Krizsan, M Stitch… - Journal of the …, 2021 - ACS Publications
Assessment of the DNA photo-oxidation and synthetic photocatalytic activity of chromium
polypyridyl complexes is dominated by consideration of their long-lived metal-centered …

How nature covers its bases

S Boldissar, MS de Vries - Physical Chemistry Chemical Physics, 2018 - pubs.rsc.org
The response of DNA and RNA bases to ultraviolet (UV) radiation has been receiving
increasing attention for a number of important reasons:(i) the selection of the building blocks …