Abstract “Triterpenoids” can be considered natural products derived from the cyclization of
squalene, yielding 3-deoxytriterpenes (hydrocarbons) or 3-hydroxytriterpenes. Triterpenoids …

Metabolic reprogramming represents a hallmark of tumorigenesis to sustain survival in
harsh conditions, rapid growth and metastasis in order to resist to cancer therapies. These …

The production of terpenoids from engineered microbes contributes markedly to the
bioeconomy by providing essential medicines, sustainable materials, and renewable fuels …

Polysaccharide is one of the main active ingredients of Polygonatum kingianum, which has
been proven to regulate the balance of gut microbiota. For the first time, this study focused …

In general, computational simulations of enzymatic catalysis processes are thermodynamic
and structural surveys to complement experimental studies, requiring high level …

Biocatalysis (the use of biological molecules or materials to catalyse chemical reactions) has
considerable potential. The use of biological molecules as catalysts enables new and more …

Mevalonate kinase is central to the isoprenoid biosynthesis pathway. Here, high-resolution
X-ray crystal structures of two mevalonate kinases are presented: a eukaryotic protein from …

Mevalonate diphosphate decarboxylase (MDD) catalyses a crucial step of the mevalonate
pathway via Mg2+-ATP-dependent phosphorylation and decarboxylation reactions to …

The primary objective of this dissertation is to elucidate the mevalonate (MVA) pathway of
Saccharomyces cerevisiae for enhanced production of isopentenyl pyrophosphate (IPP) …

Computational studies on the reactivities of cyanoacrylamide-based Bruton's Tyrosine
Kinase (BTK) inhibitors have been performed through quantum mechanical (QM) …