The field of photopharmacology uses molecular photoswitches to establish control over the
action of bioactive molecules. It aims to reduce systemic drug toxicity and the emergence of …

Ribonucleotide reductases (RNRs) transform RNA building blocks to DNA building blocks
by catalyzing the substitution of the 2′ OH-group of a ribonucleotide with a hydrogen by a …

The differential transcriptional response of Mycobacterium tuberculosis to drugs and growth-
inhibitory conditions was monitored to generate a data set of 430 microarray profiles …

Human tuberculosis is a complex disease caused by bacterial populations that are located
in discrete lesions (microenvironments) in a single host. Some of these microenvironments …

Mycobacterium tuberculosis contains five resuscitation‐promoting factor (Rpf)‐like proteins,
RpfA‐E, that are implicated in resuscitation of this organism from dormancy via a mechanism …

Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …

Mycobacterium tuberculosis is predicted to subsist on alternative carbon sources during
persistence within the human host. Catabolism of odd-and branched-chain fatty acids …

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease
despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M …

Pathogenetic processes that facilitate the entry, replication, and persistence of
Mycobacterium tuberculosis (MTB) in the mammalian host likely include the regulated …

Despite the presence of genes that apparently encode NAD salvage-specific enzymes in its
genome, it has been previously thought that Mycobacterium tuberculosis can only …